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Therapeutic candidates that were screened in vitro
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Therapeutic candidates that were screened in vitro

Journal: Arthritis Research & Therapy

Article Title: Randomized controlled studies on the efficacy of antiarthritic agents in inhibiting cartilage degeneration and pain associated with progression of osteoarthritis in the rat

doi: 10.1186/s13075-016-0921-5

Figure Lengend Snippet: Therapeutic candidates that were screened in vitro

Article Snippet: NF-κB activation inhibitor IV [resveratrol derivative (E)-2-fluoro-4′-methoxystilbene] 481412 (Calbiochem) , 228.1 , Experimentally used as an anti-inflammatory but not an antioxidant 130-fold more potent than resveratrol at inhibiting NF-κB [ ] , , Not clinically approved.

Techniques: Activity Assay, Binding Assay, Activation Assay, Phospho-proteomics, Expressing, Formulation, Clinical Proteomics, Blocking Assay, Synthesized, In Vitro, Positive Control, Saline, In Vivo, Polymer, Injection

Efficacy of drugs in NF-κB, MMP-13, and bone remodeling assays

Journal: Arthritis Research & Therapy

Article Title: Randomized controlled studies on the efficacy of antiarthritic agents in inhibiting cartilage degeneration and pain associated with progression of osteoarthritis in the rat

doi: 10.1186/s13075-016-0921-5

Figure Lengend Snippet: Efficacy of drugs in NF-κB, MMP-13, and bone remodeling assays

Article Snippet: NF-κB activation inhibitor IV [resveratrol derivative (E)-2-fluoro-4′-methoxystilbene] 481412 (Calbiochem) , 228.1 , Experimentally used as an anti-inflammatory but not an antioxidant 130-fold more potent than resveratrol at inhibiting NF-κB [ ] , , Not clinically approved.

Techniques: In Vivo, Control, Activation Assay